The Binding Of Isaac: Rebirth

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Cheat Codes

Display the Seed entry prompt at the "Character Select" menu by pressing [Tab]. Then, enter one of the following seed codes to activate the corresponding cheat function. You can remove any codes by pressing Q + E + [Tab] or LB + RB + X on an Xbox controller. Note: Entering a seed code will prevent achievements from being earned. Additionally, some codes may delete your saved game file.

Result Seed Code
Easier game 1337 HAXR
Start with 69 coins and have to purchase all items and pickups FREE 2PAY or PAY2 PLAY
Large pools of blood when enemies die BL00 00DY
Character leaves fecal trail BRWN SNKE
Sound effects replaced with farts FART SNDS
All enemies have permanently feared FEAR M1NT
All items except troll bombs mimic Issac's movement KEEP AWAY
Character only visible as brown shadow CAM0 K1DD
Enemies only visible as brown shadows CAM0 F0ES
Invisible character except for surrounding light effect 1MN0 B0DY
Invisible enemies BL1N DEYE
Enemies respawn when character leaves room; new items do not drop C0ME BACK
Enemies fight each other C0CK FGHT orCLST RPH0
Eligible enemies become champions CHAM P10N
Concussive enemies that move randomly C0NF ETT1
Reversed controls DRAW KCAB
Tarot cards are face down when collected FACE D0WN
Enemies become feared randomly FRAI DN0T
Grey character KAPP A
The lower your health, the slower the music HART BEAT
Pill names and descriptions appear as ??? MED1 C1NE
Can destroy rocks NFB8 3WSG
Doors open immediately, tears are harmless; Boss's health act as timers PAC1 F1SM or PAC1 F1ST
Character and tears turn black PTCH BLCK
Ticking starts every 45 seconds, after 5 seconds character takes half heart of damage THEG H0ST
Take damage when idle D0NT ST0P
Character takes double damage HARD HARD
Slow motion while character is idle; music speed altered with movement speed SL0W 4ME2
Jumbled in-game text DYSL EX1C
CRT display B00B T00B
All floors have the basement room tile set BASE MENT
Load screen always displays "Are You Sure You Want Me To Die?" 1TEN DSHE or SUPA SWAG
Unknown KEEP TRAK
Unknown B911 99AC
Unknown 8AJJ AASE
Unknown B911 TCZL
Unknown TAR0 TARJ
Unknown 1SAA AACE
Unknown XXXX XXZX
Unknown GGGG GGGG
Unknown N1CA L1SY

The following codes can be used in the "Afterbirth" DLC:

Result Seed Code
30 minute limit30M1 N1TS
Asocial enemiesCLST RPH0
Axis aligned controlsAX1S ALGN
Big head modeT0PH EAVY
Black bodyPTCH BLCK
BraveryBRAVERY
Camouflage enemiesCAM0 F0ES
Camouflage EVERYTHING!WH0A WHAT
Camouflage playerCAM0 K1DD
Camouflage stuffCAM0 DR0P
Cathode rays!B00B T00B
Champion enemiesCHAM P10N
Charmed enemiesC0CK FGHT
ChristmasCHRS TMAS
Confused enemiesC0NF ETT1
CowardiceC0WR D1CE
Damage on a timerTHEG H0ST
Dog ModeALM1 GHTY
Don't stop movingD0NT ST0P
DowntempoANDA NTE
Downtempo--LARG HET0
DyslexiaDYSL EX1A
Enemies respawnC0ME BACK
Escape the LabyrinthTHRE AD
Extra GoreBL00 00DY
F2P versionFREE 2PAY
Farty soundsFART SNDS
Forever UnknownVNKN 0WN
Full heart damageHARD HARD
Glowing tearsTEAR GL0W
GrayscaleKAPP A
Heal the BlindBRA1 LLE
Health tempoHART BEAT
Hopelessly LostL0ST
Horrible CurseCVRS ED
I once was LostF0VN D
Ice Physics1CES KATE
Illuminate DarknessN1TE L1TE
Incurable BlindnessBL1ND
Inescapable LabyrinthLABY RNTH
Infinite BasementsBASE MENT
Invisible enemiesBL1N DEYE
Invisible player1MN0 B0DY
Kids' co-op modeK1DS M0DE
Know the UnknownN0W1 KN0W
Movement tempoSL0W 4ME2
Mystery cardsFACE D0WN
Mystery pillsMED1 C1NE
No HUDKEEP TRAK
PacifismPAC1 F1SM
Permanent DarknessDARK NESS
Pickups time outG0NE S00N
Point of no returnN0RE TVRN
Poopy TrailBRWN SNKE
Reversed controlsDRAW KCAB
Scaredy enemiesFEAR M1NT
Skittish enemiesFRA1 DN0T
Stay out of the MazePATH F1ND
The BlankTHEB LANK
Tiny head modeT1NY D0ME
Total curse ImmunityBLCK CNDL
Tricky pickupsKEEP AWAY
Twelve heart damageBRTL B0NS
Unending MazeMAZE
UptempoALLE GR0
Uptempo++PRES T0

Enable mouse controls

Note: This procedure involves editing a game file; create a backup copy of the file before proceeding. Use a text editor to edit the "Options.ini" file in the "\Documents\My Games\Binding of Isaac Rebirth" directory. Change the "MouseControl=0" line to "MouseControl=1".

Bonus characters

Successfully Complete the indicated task to unlock the corresponding character:

    ???: Defeat Mom's Heart ten times. ??? starts with three Soul Hearts, and has The Poop (spawns a poop, recharges once per room).

    Azazel: Make three deals with the Devil in one run. Azazel has the "0 - The Fool" ability, which can teleport you to the current floor's starting room. He starts with three Demon Hearts as health. When a Demon Heart is lost, damage is dealt to all enemies in the room. He can fire a short-range Brimstone beam, and can fly over hazards.

    Cain: Have at least 55 pennies at once. Cain starts with one regular key, and has the "Lucky Foot" ability, which increases Luck.

    Eden: Successfully complete "The Womb" chapter. Using Eden requires a special token obtained by defeating Mom's Heart or It Lives.

    Eve: Do not collect any Hearts (Red, Spirit, Eternal, or Demon) for two floors. Eve has the "Dead Bird" (dead bird spawns when hit and attacks enemies) and "W'hore Of Babylon" (increased damage and speed when at one heart) abilities.

    Judas: Defeat Satan. Judas starts with three pennies, and has the Book Of Belial, which increases damage for the current room. It recharges once every three rooms.

    Lazarus: Have four Spirit Hearts at once. Lazarus has a random pill. He can revive once upon death with a Red Heart container and the "Anemic" ability (leaves blood trail in current room that damages enemies when damage is taken).

    Magdalene: Have at least seven Red Heart containers at once. Magdalene starts with a Yum Heart, which heals one heart upon use. It recharges once every four rooms.

    Samson: Do not take damage for two floors. Samson has the "Bloody Lust" ability, which increases his damage dealt each time he takes damage. The bonus damage resets with each floor.

    The Lost: Die in the following specific manners, in order in the same game session without any other type of death in-between. Have Isaac die by a Mulliboom's explosion in either the Basement or Cellar. Have Magdalene die by your own bomb in either the Caves or Catacombs. Have Judas die by Mom. Have Azazel die by Satan during his second phase in Sheol. The Lost can fly, cannot pick up hearts or have health increase, Devil Room items can be taken without penalty, and dies if the game is left idle.

Bonus items

Successfully complete the indicated task with the listed character to unlock the corresponding item:

???

    ???'s Only Friend: Defeat Boss Rush.
    Fate: Defeat Boss Rush.
    Forget Me Now: Defeat Satan.
    D6: Defeat Isaac.
    ???'s Soul: Defeat The Dark Room.

Azazel

    The Nail: Defeat Boss Rush.
    Daemon's Tail: Defeat Satan.
    The Satanic Bible: Defeat Isaac.
    Abaddon: Defeat The Chest.
    Demon Baby: Defeat The Dark Room.

Cain

    Sack Of Pennies: Defeat Isaac.
    Cain's Other Eye: Defeat Boss Rush.
    Bomb Bag: Defeat Satan.
    Cain's Eye: Defeat The Chest.
    Abel: Defeat The Dark Room.

Eden

    Undefined: Defeat Boss Rush.
    The Book Of Secrets: Defeat Satan.
    A Blank Card: Defeat Isaac.
    Mysterious Paper: Defeat The Chest.
    Mystery Sack: Defeat The Dark Room.

Eve

    Eve's Mascara: Defeat Boss Rush.
    Razor Blade: Defeat Satan.
    Eve's Bird Foot: Defeat Isaac.
    Sacrificial Dagger: Defeat The Chest.
    Black Lipstick: Defeat The Dark Room.

Issac

    Isaac's Head: Defeat Boss Rush.
    Mom's Perfume: Defeat Isaac.
    D20: Defeat The Chest.
    Missing Poster: Defeat The Dark Room.

Judas

    Judas' Shadow: Defeat Boss Rush.
    Judas' Tongue: Defeat Satan.
    Guillotine: Defeat Isaac.
    Curved Horn: Defeat The Dark Room.

Lazarus

    Broken Ankh: Defeat Satan.
    Lazarus' Rags: Defeat Isaac.
    Pandora's Box: Defeat The Dark Room.

Magdalene

    The Relic: Defeat Isaac.
    Maggy's Bow: Defeat Boss Rush.
    Guardian Angel: Defeat Satan.
    Celtic Cross: Defeat The Chest.
    Maggy's Faith: Defeat The Dark Room.

Samson

    Samson's Chains: Defeat Boss Rush.
    Blood Rights: Defeat Satan.
    Bloody Lust: Defeat Isaac.
    Bloody Penny: Defeat The Chest.
    Samson's Lock: Defeat The Dark Room.

The Lost

    D100: Defeat Boss Rush.
    The Mind: Defeat Satan.
    Isaac's Heart: Defeat Isaac.
    The Body: Defeat The Chest.
    The Soul: Defeat The Dark Room.

Easy items

This trick requires the Blank Card (from defeating Isaac in the Cathedral with Eden), Jera Rune (from completing the "High Brow" challenge), and the D20 (from defeating ??? in the Chest with Isaac). Having the D6 (from defeating Isaac in the Cathedral with ???) is also helpful. Start by finding a room that has at least one battery on the ground. Alternately, spawn them with the 48 Hour Energy pill. Remove all other items from the room. Use charges from somewhere else to copy those batteries with the Blank Card and Jera until you have at least three of them. Use batteries from the room to copy batteries for a net gain. Keep doing this until the room is filled with batteries to virtually have infinite charges for any activated item. Then, obtain a Judgement card (from Wheel Of Fortune cloning, Tarot Deck, etc.). Use the Blank Card and Jera in a new room to copy a large number of Judgement cards. Go to another new room, and copy a large number of coins, keys and hearts. Note: Try spawning a few Beggars and bombing them. Use the resources in this room to refill when required. If you need a D20, use the Judgement cards to spawn Beggars and farm them until you get one from a Key Beggar chest. Finally, use the following four steps to complete the process:

    1. Fill the largest room available with items such as coins. A room is considered full when it starts replacing old items with new ones.

    2. Use the D20 to reroll the items, open all the chests, pick up any passive items, pills, and other helpful objects and repeat. Avoid collecting items that are not needed.

    3. Once a D6 drops, repeat the steps in a smaller room to get a few activated items. Swap any activated items that you want to keep elsewhere.

    4. Reroll the items in the main room with the D6, collect anything desired, and repeat the process. Use the D20 to refill as needed.

Zodiac items

Collect the listed item to gain the corresponding effect:

    Aquarius: Leave trail of tears that damage enemies.
    Aries: Movement speed increases, and grows horns on head that can damage enemies.
    Cancer: Get three spirit hearts, the ability to inflict poison on contact, and convert damage over time into half hearts.
    Capricorn: All stats increased, get one bomb, and key and coin.
    Gemini: Gemini's baby appears on Isaac and damages nearby enemies.
    Leo: Break rocks by walking on them.
    Libra: Get six keys, bombs and coins, and have all stats balanced.
    Pisces: Tear upgrade and their knockback is increased.
    Sagittarius: Tears are piercing and have faster rate.
    Scorpio: Tears are poisonous, and tear stats lowered.
    Taurus: Movement speed decrease but gets faster when enemies are present. When fast enough, can damage enemies on contact.
    Virgo: Empty red heart containers refilled, and get temporary shield once per room.

Trinket effects

Equip the indicated trinket to gain the corresponding effect:

    ???'s Soul: Spawns a familiar that floats slowly around the room on a pattern close to The Peeper and fires spectral and homing tears.
    AAA Battery: Automatically recharges the last energy slot of an activated item, reducing recharge rates by one.
    Ace of Spades: Increases the chance of tarot cards or playing cards dropping after clearing a room, and the chance of finding cards when opening a chest.
    Bible Tract: Increases chance for Eternal Hearts to appear.
    Black Lipstick: Increases the chance of Devil Rooms and Black Hearts appearing. Lowers the chance of Angel Rooms and Eternal Hearts appearing. Presented to the player with "Evil Up"
    Bloody Penny: 50% chance to drop a half heart when money is collected.
    Broken Ankh: Isaac has a chance to be revived as ???. Can occur multiple times.
    Broken Magnet: Pulls coins towards Isaac.
    Broken Remote: Triggers the Teleport effect when an activated item is used.
    Burnt Penny: 50% chance to drop a bomb when collected.
    Butt Penny: Isaac will fart when he picks up a coin.
    Cain's Eye: When starting a floor, 25% chance to get the Compass effect for the duration of that floor.
    Callus: Prevents damage from creep and spikes.
    Cancer: Increases Tears by 2.
    Cartridge: Chance to trigger The Gamekid effect upon taking damage.
    Child's Heart: Increases the chance of a Heart dropping after clearing a room, and the chance of finding a Heart when opening a Chest.
    Counterfeit Penny: 50% chance of increasing the value of every coin pickup by one.
    Cursed Skull: If Isaac has less than one full red heart after taking damage, he will be teleported to the last cleared room he was in.
    Curved Horn: increases damage by 2.
    Daemon's Tail: Large chance of any non-specific Heart drop turning into a Black Heart.
    Eve's Bird Foot: 5% chance to spawn a Dead Bird familiar for the current room each time an enemy dies.
    Fish Head: Spawns a Blue Fly every time Isaac takes damage.
    Flat Penny: 50% chance of spawning a key upon collecting a penny.
    Flat Worm: Isaac's tears take on an oblong appearance. They also push enemies back.
    Goat Hoof: Increases speed by 0.15.
    Hook Worm: Tears move shifting left to right forming a path of right angles. +10 to Range.
    Isaac's Head: Isaac's severed head as a tear-firing familiar. Fires piercing tears.
    Isaacs's Fork: Isaac a 10% chance for being healed 1/2 a red heart upon clearing a room.
    Judas' Tongue: Items in the Devil Room only to cost 1 heart. Soul heart trades still cost 3 Soul hearts.
    Liberty Cap: Chance of giving Isaac a random passive effect from Mushroom Items as well as its corresponding visual effect upon entering a room. Has also 20% chance of granting the compass effect upon entering a room.
    Lucky Rock: Rocks and mushrooms drop coins upon being destroyed.
    Lucky Toe: Increases the chance to get a drop after clearing a room. Although the Luck stat also influences this, it does not actually increase the Luck stat.
    Maggy's Faith: Eternal heart at the start of every floor.
    Match Stick: Increases the chance of Bombs dropping after clearing a room, and the chance of finding Bombs when opening a Chest.
    Missing Poster: If Isaac dies in a Sacrifice Room, a puzzle piece will appear on his last will.
    Mom's Pearl: Secondary 10% chance of any non-specific Heart drop turning into a Soul Heart.
    Mom's Tonenail: Mom's foot randomly stomps down somewhere in the room. One minute intervals.
    Monkey Paw: If the character has half a red heart or no red hearts after taking damage, it grants a Black Heart. The effect can trigger up to three times, after which the trinket will disappear.
    Mysterious Candy: Isaac farts or poops at random intervals. Getting hit can also trigger the effect.
    Mysterious Paper: Chance to trigger the effect of The Polaroid or The Negative every time damage is taken if the character has only half a red heart or no red hearts.
    Paper Clip: Golden Chests to be opened without using a key.
    Petrified Poop: Increases the chances of a pickup dropping when destroying poop.
    Pinky Eye: Adds a 10% chance to shoot a poison tear, dealing damage over time when inflicted.
    Pulse Worm: Shots pulse in size.
    Purple Heart: Increases chance for challenge rooms to be boss challenge rooms. Causes more enemy champions to spawn.
    Push Pin: Adds a 10% chance to shoot a piercing and spectral tear.
    Red Patch: Chance of increasing damage by 1.8 for the current room upon taking damage.
    Ring Worm: Gives Isaac spinning shots.
    Rosary Bead: Increases the chance of Angel Rooms and Eternal Hearts appearing. Present to the Isaac with "Faith Up"
    Rusted Key: Improves the chance of keys and golden chests dropping after clearing a room, and chance of finding a key when opening a chest.
    Safety Cap: Improves the chance of Pills dropping after clearing a room, and chance of finding a Pill when opening a Chest.
    Samson's Lock: 1 in 15 chance to increase damage by 0.5 for the current room each time an enemy dies.
    Store Credit: Next store purchase is free. The trinket disappears on purchase.
    Swallowed Penny: Isaac drops a penny upon taking damage.
    The Left Hand: Replaces Brown Chests and Golden Chests with Red Chests.
    The Tick: Drains 15% health of each enemy with more than 60 HP. Also restores one red heart of Isaac whenever he enters an uncleared boss room. The Tick cannot be swapped out for another trinket.
    Umbilical Cord: Spawns a Little Steven familiar for the current room when Isaac's health is brought to half a red heart and no soul hearts.
    Whip Worm: Increases shot speed by 1 and increases range.
    Wiggle Worm: Gives Isaac's shots a wave-like trajectory and increases rate of fire.

Character stats

The following is a list of health, speed, and attack stats for all characters:

NameHealthSpeedAttack
??? -1 2 2
Azazel -1 2 3
Cain 2 2 2
Eden Random Random Random
Eve 2 2 1
Isaac 3 2 2
Judas 1 2 3
Lazarus 3 2 2
Magdalene 4 1 2
Samson 3 2 1
The Lost 0 2 2

Easy "Godhead" achievement

Successfully complete all goals on the sticky note (defeat all Bosses and Boss Rush) with The Lost in Hard mode to get the "Godhead" achievement. Goals completed in that mode will have a red outline around their icons. Note: If the "Afterbirth" DLC is installed, you will also have to defeat Mega Satan and the two new Bosses in Hard mode.

Easy "Platinum God" achievement

Unlock all other achievements and collect every pedestal item to get the "Platinum God" achievement.

Easy "The Body" achievement

Defeat ??? (Boss of The Chest) with The Lost to get "The Body" achievement. Note: Items that revive you as a different character (for example, Judas' Shadow or Broken Ankh) will disqualify your progress if you die and are revived.

Easy "The Mind" achievement

Defeat Satan (Boss of Sheol) with The Lost to get "The Mind" achievement. Note: Items that revive you as a different character (for example, Judas' Shadow or Broken Ankh) will disqualify your progress if you die and are revived.

Easy "The Soul" achievement

Defeat The Lamb (Boss of the Dark Room) with The Lost to get "The Soul" achievement. Note: Items that revive you as a different character (for example, Judas' Shadow or Broken Ankh) will disqualify your progress if you die and are revived.

Steam achievements

Successfully complete the indicated task to unlock the corresponding achievement. To view your achievements and stats in Steam, select "Community", "My profile", "View all my games", then the game and view stats.

    ???: Defeat Mom's heart 10 times.
    ???'s Only Friend: Complete Boss Rush with ???.
    ???'s Soul: Defeat dark room with ???.
    -0- Baby: Defeat Mom's heart on hard mode with the Lost.
    A Bag of Bombs: Kill Satan with Cain.
    A Bag of Pennies: Kill Isaac with Cain.
    A Cube of Meat: Defeat Mom for the first time.
    A Fetus in a Jar: Defeat Mom's heart nine times.
    A Forget Me Now: Kill Satan with ???.
    A Gamekid: Visit 10 arcades.
    A Halo: Kill Mom using the Bible.
    A Quarter: Defeat Mom's heart 8 times.
    A Small Rock: Destroy 100 tinted rocks.
    Abaddon: Defeat chest with Azazel.
    Abel: Defeat dark room with Cain.
    Angels: Defeat chest or dark room.
    Azazel: Make 3 deals with the devil in one run.
    Basement Boy: Defeat the basement/cellar without taking damage.
    Begotten Baby: Defeat Mom's heart on hard mode with Lazarus.
    Black Candle: Donate 150 pennies to the shop.
    Black Lipstick: Defeat dark room with Eve.
    Blank Card: Kill Isaac with Eden.
    Blood Bag: Use the blood donation machine 30 times.
    Blood Lust: Kill Isaac with Samson.
    Blood Penny: Defeat the chest with Samson.
    Blood Rights: Kill Satan with Samson.
    Blue Candle: Donate 900 pennies to the shop.
    Blue Map: Donate 10 pennies to the shop.
    Book Of Revelations: Defeat a horseman for the first time.
    Book of Secrets: Kill Satan with Eden.
    Broken Ankh: Kill satan with Lazarus.
    Burnt Penny: Complete challenge #13.
    Butter Bean: Destroy 100 poops.
    Cain: Hold 55 pennies at one time.
    Cain's Eye: Defeat chest with Cain.
    Cain's Other Eye: Complete Boss Rush with Cain.
    Card Against Humanity: Complete challenge #12.
    Cat Got Your Tongue: Become Guppy (collect 3 Guppy Items).
    Celtic Cross: Defeat the chest with Maggy.
    Chaos Card: Complete challenge #9.
    Counterfeit Coin: Play the shell game 100 times.
    Credit Card: Complete challenge #10.
    Crow Baby: Defeat Mom's heart on hard mode with Eve.
    Cursed!: Unlocked Challenge #10.
    Curved Horn: Defeat dark room with Judas.
    Cute Baby: Defeat Mom's heart on hard mode with Maggy.
    D100: Complete Boss Rush with The Lost.
    D4: Blow up 30 arcade machines.
    Dad's Key: Collect a golden key.
    Dark Boy: Defeat the depths/necropolis without taking damage.
    Darkness Falls: Defeat Mom's Heart 11 times.
    Dead Baby: Defeat Mom's heart on hard mode with ???.
    Dead Boy: Defeat the chest or dark room without taking damage.
    Death's Touch: Complete challenge #17.
    Demo Man: Unlocked Challenge #9.
    Demon Baby: Defeat dark room with Azazel.
    Demon's Tail: Kill satan with Azazel.
    Dr. Fetus: Defeat Mom's heart 9 times.
    Eden: Defeat the womb for the first time.
    Epic Fetus: Complete challenge #19.
    Eve: Don't pick up any hearts for 2 levels in a row.
    Everything Is Terrible!!!: Defeat Mom's heart 5 times.
    Eve's Bird Foot: Kill Isaac with Eve.
    Eve's Mascara: Complete Boss Rush with Eve.
    Experimental Treatment: Defeat Mom's heart 7 times.
    Fate: Defeat chest with ???.
    Fighting Baby: Defeat Mom's heart on hard mode with Samson.
    Forgotten Horsemen: Take 10 items from angel rooms.
    Gish: Defeat the depths 20 times.
    Glass Baby: Defeat Mom's heart on hard mode with Cain.
    Glass Cannon: Complete Challenge 19 and kill Lokii.
    Glitch Baby: Defeat Mom's heart on hard mode with Eden.
    Godhead: Finish the game's final secret.
    Golden God!: Defeat ??? and lamb.
    Guardian Angel: Kill Satan with Maggy.
    Guillotine: Kill Isaac with Judas.
    Guppy's Hairball: Become Guppy (Collect 3 Guppy Items).
    Head of Krampus: Kill Krampus.
    Ipecac: Defeat Mom's heart 6 times.
    Isaac's Head: Complete Boss Rush with Isaac.
    Isaac's Heart: Kill Isaac with the Lost.
    Isaac's Tears: Kill Isaac with isaac.
    It Lives!: Defeat Mom's heart 11 times.
    Judas: Kill satan for the first time.
    Judas' Shadow: Complete Boss Rush with Judas.
    Judas' Tongue: Kill Satan with Judas.
    Krampus: Take 20 items from devil rooms.
    Lazarus: Have 4 or more soul hearts at one time.
    Lazarus' Rags: Kill Isaac with Lazarus.
    Lil Chubby: Defeat Caves II for the first time.
    Little Baggy: Collect 2 of either roid rage, the virus, growth hormones, experimental treatment or speed ball.
    Little C.H.A.D.: Kill C.H.A.D..
    Little Gish: Kill Gish.
    Little Steven: Kill steven.
    Loki's Horns: Defeat lokii for the first time.
    Lord of the Flies: Become lord of the flies.
    Lost Baby: Defeat Mom's heart on hard mode with Isaac.
    Lucky Rock: Destroy 100 rocks.
    Lucky Toe!: Blow up 20 shop keepers.
    Magdalene: Have 7 or more max red hearts at one time.
    Maggy's Bow: Complete Boss Rush with Maggy.
    Maggy's Faith: Defeat dark room with Maggy.
    Mamas Boy: Defeat the womb/utero without taking damage.
    Missing No.: Complete challenge #20.
    Mom's Contact: Become Mom (collect 3 Mom items in one playthrough).
    Mom's Knife: Kill Satan with Isaac.
    Monstro's Tooth: Defeat Basement II for the first time.
    Mr. Mega!: Destroy 10 tinted rocks.
    Mysterious Paper: Defeat chest with Eden.
    Mystery Sack: Defeat dark room with Eden.
    Pandora's Box: Defeat dark room with Lazarus.
    Platinum God: Collect all items in the game, unlock all of the secrets and endings minus "The Lost" and his 5 unlockable items.
    Purist: Unlocked Challenge #20.
    Real Platinum God: 100% of the game (unlock every item).
    Red Candle: Donate 400 pennies to the shop.
    Relic: Kill Isaac with Maggy.
    Robo Baby 2.0: Complete challenge #16.
    Rubber Cement: Defeat Mom's heart 2 times.
    Rules Card: Complete challenge #11.
    Rune of Algiz: Complete challenge #8.
    Rune of Ansuz: Complete challenge #5.
    Rune of Berkano: Complete challenge #7.
    Rune of Dagaz: Complete challenge #4.
    Rune of Ehwaz: Complete challenge #3.
    Rune of Hagalaz: Complete challenge #1.
    Rune of Jera: Complete challenge #2.
    Rune of Perthro: Complete challenge #6.
    Sacrificial Dagger: Defeat the chest with Eve.
    Samson: Defeat 2 levels in a row without taking damage.
    Samson's Chains: Complete Boss Rush with Samson.
    Samson's Lock: Defeat dark room with Samson.
    Satanic Bible: Kill Isaac with Azazel.
    Shadow Baby: Defeat Mom's heart on hard mode with Judas.
    SMB Super Fan: Complete challenge #14.
    Solar System: Finish the game with a full set of orbitals.
    Something Cute: Defeat the caves 30 times.
    Something From The Future!: Defeat the basement 40 times.
    Something Icky!: Defeat cathedral 10 times.
    Spelunker Boy: Defeat the caves/catacombs without taking damage.
    Stop Watch: Donate 999 pennies to the shop.
    Store Credit: Defeat chest with Lazarus.
    Store Upgrade 1: Donate 20 pennies to the shop.
    Store Upgrade 2: Donate 100 pennies to the shop.
    Store Upgrade 3: Donate 200 pennies to the shop.
    Store Upgrade 4: Donate 600 pennies to the shop.
    Suicide King: Complete Boss Rush with Lazarus.
    Super Bandage: Make a super bandage girl.
    Super Meat Boy: Build Super Meat Boy by collecting four "Cubes of Meat" or four "Ball of Bandages" in the same run.
    Swallowed Penny: Complete challenge #15.
    Technology .5: Complete challenge #18.
    The Body: Defeat chest with The Lost.
    The Book of Sin: Kill all 7 sins.
    The Catacombs: Defeat all possible Bosses in the caves.
    The Cellar: Defeat all possible Bosses in the basement.
    The D20: Defeat the chest with Isaac.
    The D6: Kill Isaac with ???.
    The Family Man: Collect Key Piece 1 and Key Piece 2 in one run by destroying Angel Statues in Angel Rooms.
    The Harbingers: Defeat Mom for the first time.
    The Lost: Die as Isaac to a Mulliboom in the basement, a bomb as Maggy in the Caves, Mom's Foot as Judas in the Depths, and Satan's second form (not the feet) as Azazel in Sheol in that order..
    The Lost Poster: Defeat dark room with Isaac.
    The Mind: Kill Satan with The Lost.
    The Nail: Complete Boss Rush with Azazel.
    The Necronomicon: Use the death card 4 times.
    The Necropolis: Defeat all possible Bosses in the depths.
    The Negative: Defeat Sheol 5 times.
    The Parasite: Collect 2 of Bob's rotten head, dead cat, Max's head, Tammy's head.
    The Polaroid: Defeat the cathedral 5 times.
    The Razor: Kill Satan with Eve.
    The Scissors: Die 100 times.
    The Soul: Defeat dark room with The Lost.
    The Tank: Unlock Magdalene.
    The Womb: Defeat Mom for the first time.
    There's Options: Donate 50 pennies to the shop.
    Transcendence: Defeat Mom's heart 3 times.
    Undefined: Complete Boss Rush with Eden.
    Unknown: Defeat Chest with Judas.
    Wire Coat Hanger: Defeat Mom's heart 4 times.
    Wrapped Baby: Defeat Mom's heart on hard mode with Azazel.

The following achievements require the "Afterbirth" bonus downloadable content:

    2 new pills: Unlocked a new item.
    2 new pills: Unlocked a new item.
    Athame: Unlocked a new item.
    Belial Baby: Unlocked a new co-player baby.
    Betrayal: Unlocked a new item.
    Big Baby: Unlocked a new co-player baby.
    Black Baby: Unlocked a new co-player baby.
    Black Feather: Unlocked a new item.
    Blank Rune: Unlocked a new item.
    Blind Rage: Unlocked a new item.
    Blinding Baby: Unlocked a new co-player baby.
    Blue Baby: Unlocked a new co-player baby.
    Blue Bomber: Unlocked Challenge #23.
    Blue Womb: Unlocked a hidden chapter.
    Box of Friends: Unlocked a new item.
    BRAINS!: Unlocked Challenge #27.
    Brown Baby: Unlocked a new co-player baby.
    Buddy Baby: Unlocked a new co-player baby.
    Cain holds Paperclip: Unlocked a new starting item.
    Cambion Conception: Unlocked a new item.
    Censer: Unlocked a new item.
    Colorful Baby: Unlocked a new co-player baby.
    Cracked Baby: Unlocked a new co-player baby.
    Cracked Dice: Unlocked a new item.
    Cry Baby: Unlocked a new co-player baby.
    D12: Unlocked a new item.
    D8: Unlocked a new item.
    Dark Baby: Unlocked a new co-player baby.
    Dripping Baby: Unlocked a new co-player baby.
    Eden's Blessing: Unlocked a new item.
    Empty Vessle: Unlocked a new item.
    Evil Eye: Unlocked a new item.
    Fart Baby: Unlocked a new co-player baby.
    Fate's Reward: Unlocked a new item
    GB Bug: Unlocked a new item.
    Generosity: ...
    Get out of Jail Free Card: Unlocked a new item.
    Goat Head Baby: Unlocked a new co-player baby.
    Gold Bomb: Unlocked a new item.
    Gold Heart: Unlocked a new item.
    Green Baby: Unlocked a new co-player baby.
    Have a heart: Unlocked Challenge #25.
    Hive Baby: Unlocked a new co-player baby.
    I RULE!: Unlocked Challenge #26.
    Immaculate Conception: Unlocked a new item.
    Incubus: Unlocked a new item.
    Key Bum: Unlocked a new item.
    Kidney Stone: Unlocked a new item.
    Lil' Baby: Unlocked a new co-player baby.
    Lil' Chest: Unlocked a new item.
    Lilith: Unlocked a new character.
    Long Baby: Unlocked a new co-player baby.
    Lucky Pennies: Unlocked a new item.
    Lusty Blood: Unlocked a new item.
    Maw of the Void: Unlocked a new item.
    My Shadow: Unlocked a new item.
    Onan's Streak: Unlocked Challenge #29.
    PAY TO PLAY: Unlocked Challenge #24.
    Picky Baby: Unlocked a new co-player baby.
    Poker Chip: Unlocked a new item.
    PRIDE DAY!: Unlocked Challenge #28.
    Purity: Unlocked a new item.
    Rage Baby: Unlocked a new co-player baby.
    Red Baby: Unlocked a new co-player baby.
    Revenge Baby: Unlocked a new co-player baby.
    Rune Bag: Unlocked a new item.
    Serpent's Kiss: Unlocked a new item.
    Special Hanging Shopkeepers: Unlocked a secret.
    SPEED!: Unlocked Challenge #22.
    Stud Finder: Unlocked a new item.
    Succubus: Unlocked a new item.
    Sucky Baby: Unlocked a new co-player baby.
    Sworn Protector: Unlocked a new item.
    The Guardian: Unlocked Challenge #30.
    White Baby: Unlocked a new co-player baby.
    Whore Baby: Unlocked a new co-player baby.
    Wooden Nickel: Unlocked a new item.
    XXXXXXXXL: Unlocked Challenge #21.
    Yellow Baby: Unlocked a new co-player baby.
    Zodiac: Unlocked a new item.
    1001%: Unlocked a new item.
    Deep Pockets: Unlocked a new item.
    Eve now holds Razor Blade: Unlocked a new starting item.
    Everything is Terrible 2!!!: Greed just got harder!
    Generosity: ...
    Karma: Unlocked a new item.
    Keeper: Unlocked a new item.
    Keeper now holds... A Penny!: Unlocked a new item.
    Keeper's Store Key: Unlocked a new item.
    Keeper's Wooden Nickel: Unlocked a new item.
    Lost holds Holy Mantle: Unlocked a new starting item.
    Mega: Unlocked...
    Noose Baby: Unlocked a new item.
    Rib of Greed: Unlocked a new item.
    Sale Baby: Unlocked a new item.
    Special Shopkeepers: Unlocked a secret.
    Sticky Nickels: Unlocked a new item.
    Store Key: Unlocked a new item.
    Super Greed Baby: Unlocked a new item.
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